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Adolescent with tetralogy of Fallot: Neuropsychological assessment and structural brain imaging. doi:10.1007/s0024-9.īellinger DC, Rivkin MJ, DeMaso D, Robertson RL, Stopp C, Dunbar-Masterson C, Newburger JW. Neurodevelopmental outcomes following congenital heart surgery. Future studies are needed in other adolescent disease groups with known cognitive deficits and healthy populations to explore the generalizability of validity of MoCA scores in adolescents and young adults.īallweg JA, Wernovsky G, Gaynor JW. Scores on the MoCA were valid for screening to detect cognitive deficits in adolescents and young adults aged 14-21 with CHD when a cutoff score of 26 is used to differentiate youth with and without significant cognitive impairment. 02) for the CHD and controls, respectively. The area under the receiver operating characteristic curve (95% CI) for the MoCA was 0.84 (95% CI, p <. A cutoff score of 26 on the MoCA was optimal in the CHD group a cutoff of 25 had similar properties except for a lower negative predictive value. 90, respectively, in the detection of cognitive deficits. With the screening cutoff scores at <26 points for the MoCA and 85 for GMI (<1 SD, M = 100, SD = 15), the CHD versus healthy control groups showed sensitivity of. The MoCA median scores in the CHD versus healthy controls were (23, range 15-29 vs. Receiver operating characteristic curves were created and area under the curve, sensitivity, specificity, positive predictive value, and negative predictive value were also calculated. To assess construct validity, the Mann-Whitney U test was used to compare differences in scores in youth with CHD and the healthy control group.
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Spearman's rank order correlations were used to assess concurrent validity. We administered the MoCA and the WRAML2 to 156 adolescents and young adults ages 14-21 (80 youth with CHD and 76 healthy controls who were gender and age matched). The purpose of the research was to validate scores from the MoCA against the General Memory Index (GMI) of the Wide Range Assessment of Memory and Learning, 2nd Edition (WRAML2), a widely accepted measure of cognition/memory, in adolescents and young adults with CHD. One candidate instrument is the Montreal Cognitive Assessment (MoCA) questionnaire. However, there is a lack of a validated brief cognitive screening tool appropriate for the outpatient setting for adolescents with CHD. Cognitive deficits are common, long-term sequelae in children and adolescents with congenital heart disease (CHD) who have undergone surgical palliation.